GW-0742 Capsules

A. Introduction

GW-0742 is an essential research tool used to investigate the physiological roles of the PPARδ isoform. As a high-affinity ligand, it is utilized by research institutions to explore the regulation of fatty acid oxidation, mitochondrial function, and inflammatory response pathways. These standardized capsules facilitate precise measurement and delivery in controlled laboratory environments.

B. Scientific Overview

Chemically identified as [4-[[[2-[3-fluoro-4-(trifluoromethyl)phenyl]-4-methyl-5-thiazolyl]methyl]thio]-2-methylphenoxy]acetic acid ($C_{21}H_{17}F_{4}NO_{3}S_{2}$), GW-0742 is a structural analogue of GW-501516. It is distinguished by the addition of a fluorine atom, which researchers study to understand its impact on binding affinity and metabolic stability. In in-vitro settings, it activates the PPARδ-mediated transcriptional program, which oversees the expression of proteins critical to energy homeostasis.

C. Product Specifications

• Form: Encapsulated powder for laboratory measurement

• Active Concentration: 10mg per unit

• Chemical Class: PPARβ/δ Agonist / Thiazole derivative

• Molecular Formula: $C_{21}H_{17}F_{4}NO_{3}S_{2}$

• Purity: ≥99% (HPLC Verified)

• Quantity: Available in standard laboratory counts

• Storage: Store at room temperature (15°C to 25°C) in a dry environment protected from light.

D. Laboratory Use Context

GW-0742 capsules are provided exclusively for in-vitro research and analytical testing. They are a critical reagent for:

• Investigating PPARδ-dependent gene expression in cardiac and skeletal muscle cell lines.

• Studying the molecular mechanisms of lipid metabolism and glucose utilization.

• Calibration and validation of LC-MS and GC-MS equipment for metabolic modulator screening.

• Comparative structural analysis between various halogenated PPAR ligands.

E. Quality & Testing

• Analytical Precision: Each batch undergoes rigorous HPLC analysis to confirm chemical purity and 10mg concentration accuracy per capsule.

• Structural Identity: Mass Spectrometry (MS) and Proton NMR verify the presence of the trifluoromethyl and fluorophenyl structural components.

• Batch Consistency: Manufactured under strict protocols to ensure reproducible results for complex longitudinal studies.

• COA: Comprehensive Certificates of Analysis are available for all institutional research requirements.

F. Shipping & Handling

Our GW-0742 capsules are dispatched in high-barrier, moisture-proof, and UV-protected packaging to maintain the chemical stability of the thiazole derivative during transit. We provide professional, discreet worldwide shipping to support the logistical needs of international research facilities and commercial laboratories.

G. Compliance Disclaimer (CLEAR & PROMINENT)

FOR RESEARCH USE ONLY. NOT FOR HUMAN CONSUMPTION. This product is a research chemical and is strictly intended for in-vitro laboratory applications and analytical testing. It is not intended for diagnostic or therapeutic use in humans or animals. No medical instructions or dosages are provided. The purchaser is solely responsible for compliance with all local and international laws regarding the acquisition and handling of this substance.