SR-9011 Powder

A. Introduction

SR-9011 is a second-generation Rev-ErbA agonist that serves as a critical tool for research institutions investigating the molecular clock. By modulating the activity of Rev-ErbA receptors, SR-9011 allows researchers to study the intersection of circadian biology, lipid metabolism, and glucose homeostasis in controlled laboratory models.

B. Scientific Overview

Chemically identified as 3-((((4-chlorophenyl)methyl)((5-nitrothiophen-2-yl)methyl)amino)methyl)pyrrolidine-1-carboxylic acid ethyl ester ($C_{20}H_{24}ClN_{3}O_{4}S$), SR-9011 is a small molecule that enhances the constitutive repressor activity of Rev-ErbA. In in-vitro assays, it is utilized to suppress the expression of core clock genes such as BMAL1 and CLOCK. Its study provides essential data on the pharmacological regulation of the REV-ERB/BMAL1 transcriptional loop.

C. Product Specifications

• Form: Crystalline powder

• Chemical Class: Rev-ErbA Agonist

• Molecular Formula: $C_{20}H_{24}ClN_{3}O_{4}S$

• Molecular Weight: 437.94 g/mol

• Purity: ≥99% (HPLC/NMR Verified)

• Solubility: Soluble in DMSO (up to 50 mg/mL) and Ethanol

• Storage: Store in a cool, dry environment (15°C to 25°C) in an airtight container; protect from light and moisture.

D. Laboratory Use Context

This pure powder format is provided exclusively for in-vitro research and analytical testing. It is an ideal reagent for:

• Investigating Rev-ErbA-mediated gene transcription in cell cultures.

• Studying the molecular mechanisms of the circadian clock in metabolic tissues.

• Calibrating LC-MS and GC-MS equipment for metabolic modulator screening.

• In-vitro stability and toxicity profiling in synthetic biological matrices.

E. Quality & Testing

• HPLC Verification: Every batch is verified for chemical purity and the absence of related synthesis precursors.

• Structural Identity: Mass Spectrometry (MS) and Proton NMR ensure the correct identification of the pyrrolidine and thiophene structural components.

• Batch Consistency: Rigorous manufacturing standards ensure that every unit provides reproducible results for long-term longitudinal studies.

• COA: Detailed Certificates of Analysis are available for all institutional research requirements.

F. Shipping & Handling

Our SR-9011 powder is dispatched in professional, vacuum-sealed, and UV-protected packaging to maintain the stability of the compound during transit. We provide reliable, discreet worldwide shipping to research facilities and commercial laboratories, ensuring all necessary documentation is included for compliant logistics.

G. Compliance Disclaimer (CLEAR & PROMINENT)

FOR RESEARCH USE ONLY. NOT FOR HUMAN CONSUMPTION. This product is a research chemical and is strictly for in-vitro laboratory applications and analytical testing. It is not intended for diagnostic or therapeutic use in humans or animals. No instructions for administration or medical dosages are provided. The purchaser assumes all responsibility for compliance with local and international regulations regarding the acquisition and handling of this substance.